Fudan University's Zhu Xi Research Group has developed a new and effective book peptide - or will help colorectal cancer immunotherapy June 17, 2019 Source: Science Network The Zhu Xi Research Group of the School of Pharmacy of Fudan University has carried out research on large-scale chemical modification and screening based on previous work published in Science-Transformation Medicine, and obtained specific B-cell lymphoma protein 9 (BCL9) and Beta-catenin (beta-catenin) is an all-hydrocarbon "book peptide" type inhibitor. The "book peptide" was found to strongly inhibit the activity of the Wnt pathway and exhibited a good antitumor effect in a mouse tumor model. Related research results were recently published online in Science-Progress. Colorectal cancer is the fourth cancer death rate in China. Therefore, finding more targets and more effective drugs is essential to improve the overall efficacy of colorectal cancer. In colorectal cancer, more than 90% of tumors have abnormal activation of the beta-catenin pathway. At the same time, beta-catenin transcriptional signal also plays an important role in the regulation of tumor immune microenvironment, which can regulate the infiltration and activity of various types of T cells in tumors. Therefore, the development of effective beta-catenin inhibitors has the potential to resist tumors and regulate immunity, and has great medical value and practical significance. The researchers found that in addition to having good pharmacokinetic properties, the "book peptide" is very toxic in small animals, which is also the inhibition of most of the "beta peptide" compared to the current beta-catenin. The advantage of the agent. By carefully comparing the anti-tumor effects of the "book peptide" in different strains of mice, the researchers also found that the "book peptide" inhibited mouse colon cancer tumors in immunocompetent mice better than The role in nude mice. The combination of the "book peptide" and the PD-1 inhibitor can synergistically exert an effect of inhibiting tumor growth. Clinically, they also found that in colorectal cancer with adenoma polyposis protein mutations, the content of T-regulated cells was significantly increased. Professor Zhu Xi said that the results of the study indicate that the "book peptide" can not only directly inhibit the growth of colorectal cancer, but also play a role in PD-1 inhibitors in colorectal cancer in which most of the beta-catenin transcriptional signal is over-activated. The effect of sensitization. It is reported that the work was completed by Zhu Xi and researcher Feng Yuxiong of Zhejiang University. Related paper information: https://advances.sciencemag.org/content/5/5/eaau5240 The bearing structure, fixed film systems and installation of this greenhouse is relatively simple. And due to it, raw material and manufacturing costs are affordable. Except the high strength woven film is higher, other kinds of antidrop film are economical. In general, the comprehensive cost of film greenhouse is lower 30% ~ 50% than the same size and specifications of the other types of greenhouse. Single Span Greenhouse,Greenhouse Film,Tunnel Greenhouse,Plastic Film Greenhouse JIANGSU SKYPLAN GREENHOUSE TECHNOLOGY CO.,LTD , https://www.skyplantgreenhouse.com
Fudan University's Zhu Xi Research Group has developed a new and effective book peptide - or will help colorectal cancer immunotherapy
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