Tumor immune escape mechanism was discovered October 30, 2018 Source: Health News Network After nearly 6 years of research, Xu Jiejie, an associate researcher at Fudan University, found that interleukin-23 secreted by macrophages in clear cell renal cell carcinoma has an important destructive effect in inducing anti-tumor immunosuppression and tumor immune escape. Clear cell renal cell carcinoma is of great significance. Recently, related papers were published online in the international journal of Urology, European Urology. Clear cell renal cell carcinoma is a type of renal cell carcinoma that is derived from "defective" normal cells. The rate of proliferation is calculated by doubling time, and more than one billion are accumulated. As cancer cells continue to multiply, the faster the cancer develops, the later. Clear cell renal cell carcinoma is not sensitive to chemotherapy and radiotherapy, such as residual cancer tissue in the operation, the prognosis is very poor; the disease is the most common type of primary renal tumor in adults, accounting for 90% of renal malignancies, more common in In the 60-year-old population, more men than women; the cause is unknown; mostly asymptomatic hematuria as the initial symptom, gradually appearing low back pain and can reach the mass. Xu Jiejie's group has long been concerned about the role of abnormal and remodeling of the immune microenvironment of clear cell renal cell carcinoma in the development of tumors and drug resistance. The study found that immune cells such as macrophages, neutrophils and other cytokines in tumors. The expression distribution is closely related to the progression and metastasis of clear cell renal cell carcinoma, and is regulated by abnormal activation molecules of tumor cells, suggesting that they can be used as an emerging immunotherapy target for clear cell renal cell carcinoma. Further research by the research team found that clear cell renal cell carcinoma has a large intake and abnormal metabolism of glutamine to meet its malignant proliferation requirements compared with other tumors. By testing the tumor tissue of the patient, the research team found that the glutamine-prone kidney cancer tissue contains a very high expression of interleukin-23, and this high expression is positively correlated with tumor infiltration, and interleukin 23 has a strong inhibitory effect on human tumors. The damaging effects of the immune response. The research group based on a large sample of clinical cohort studies finally showed that the high expression of interleukin 23 in clear cell renal cell carcinoma is closely related to the poor survival of patients with tumors, and the tumor tissue culture and mouse tumor formation experiments also showed that the interleukin 23 inhibitor has Activate anti-tumor immunity and improve the survival of mice. Fu Qiang, Jiang Qi, School of Basic Medicine, Fudan University, Xu Le, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, and Wang Yiwei, the Ninth People's Hospital of Shanghai Jiaotong University School of Medicine, are the co-first authors of the paper. NINGBO MEDICAL EQUIPMENT CO.,LTD , https://www.techartmeds.com
Tumor immune escape mechanism was discovered