Ibrutinib is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK) that is important in B cells; the drug is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinemia, a form of non-Hodgkin's lymphoma.
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Symptoms: The typical symptom of the disease is wilting, and the entire growth period of melons can be affected. However, it is most severe when the vines reach the result stage. After sowing, it can cause rotten seedlings, and the cotyledon or whole-plant wilting occurs at the seedling stage, and the base of the stem becomes brown and shrinking, showing a cataplexy. The onset occurred at the flowering stage until the fruit setting stage. At the early stage of disease, the plants showed that the leaves gradually wilted from the base to the top, especially at noon, and recovered sooner or later. After several days, all the original plants were wilting and no longer returned to the normal state. Shrinking, rough skin, often with longitudinal cracks, when the disease is wet, the rhizomes are watery and rot, and the surface often produces white or pink moldy material.
Prevention and control: The cultivation and management should be strengthened, and the rotation should be used for rotation, the selection of disease-resistant varieties, rational irrigation as the center, and chemical control as the auxiliary comprehensive prevention and control. Seeds should be cleared before sowing, 40% formaldehyde with shallow 150 times liquid soaking 30 minutes or seed weight of 0.2 ~ 0.3% of the enemy or carbendazim seed dressing. Strengthen the cultivation and management, non-dip irrigation and string irrigation, reasonable with fertilizer, can enhance plant disease resistance. Chemical control: Before the sowing, the disease can be seriously applied to the soil, the ratio of medicine to soil is 1:100, and the bottom of the hole is covered with a cover and covered with soil. 50% carbendazim or 50% thiophanate-methyl may be used as an agent; in the early stage of disease, when a sporadic diseased plant is found, benzoate, carbendazim, or 500-1000 times diluted liquid may be used to water the plant roots.
Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, and marginal zone lymphoma.
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Attention to melon wilt
Melon wilt disease Melon wilt is one of the serious diseases of melons, often causing death of a large number of melon fields. It is a systemic disease that is invaded by soil (nutrient fluid) and invades the vascular bundles from the roots and roots.