Scientists have found the culprit to help cancer cells hide, cancer is no longer medicine-free

Scientists have found the culprit to help cancer cells hide, cancer is no longer medicine-free

Release date: 2017-05-09



At the May 2017 Immunology Annual Meeting, scientists from the University of South Carolina Medical School pointed out that platelets are the umbrellas that help cancer cells hide themselves and evade immune system attacks. If during the treatment, platelet inhibitors such as aspirin are added. It can greatly improve the treatment effect. In this study, scientists demonstrated how platelets help cancer cells escape the immune system.

The researchers found that molecules released by platelets can inhibit the activity of anti-cancer T cells. This molecule, called TGF-beta, has long been identified as the main culprits in cancer cell growth, but for the first time in TGF-beta research, this is the first time that most TGF-beta molecules are in our bodies. Inactive, scientists have discovered a protein called GARP on the surface of platelets that makes TGF-beta active. Platelets responsible for coagulation are the sole source of TGF-beta, which enters tumor cells and helps them escape the ambush of the immune system. In other words, platelets are invisible cloaks of cancer cells.

For many years, scientists have understood that specific cells inhibit T cells and thus evade the pursuit of the immune system, which is why T cell adoption is one of the current recommended methods of anti-cancer, by retraining T cells. An immunotherapy that allows cancer cells to be found, T cells are separated from the patient's blood, imprisoned, and retrained to identify cancer cells. They are then reinjected into the patient to fight cancer.

Source: Noble

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