Gao Runlin: It is safe to place a drug stent in a coronary heart patient.

Release date: 2006-11-10

Gao Runlin: It is safe to put a drug stent in patients with coronary heart disease. At the 17th Great Wall International Cardiology Conference, our famous cardiovascular disease expert Gao Runlin answered questions from reporters about the safety of drug stents. He pointed out that drug stents It did increase the incidence of thrombosis after one year, increasing by 0.2% per year, but drug stents did not increase death and myocardial infarction. Therefore, the safety of the drug stent is no problem.
However, there are signs of late-onset late thrombosis. The official website of the United States issued a statement that the FDA has been closely watching security issues since the drug stent was launched in the United States in 2003. Until now, it is believed that drug stents are safe and effective in approved indications.
At present, there are three main methods for treating coronary heart disease: drug therapy, interventional therapy and surgical coronary artery bypass grafting.
Interventional therapy for coronary heart disease does not require surgical thoracotomy. No general anesthesia is required. The patient is awake during treatment. Under the X-ray, a narrow coronary artery can be opened from the lumen of the blood vessel. Therefore, it is called interventional therapy.
At present, the basic techniques commonly used are percutaneous transluminal coronary angioplasty (PTCA) and second intracoronary stent implantation.
The advantage of coronary stenting is that it can achieve better expansion of the stenotic lesions, reduce the rate of restenosis after PTCA by half, and make the intimal tear of the coronary artery intimately adhere to the wall, reducing the occurrence of complications during surgery. Improve surgical success and safety.
The drug-coated stent is prepared by mixing the drug directly or with a polymer matrix and coating the surface of the stent to make the stent a local drug delivery system. In this way, the local concentration and duration of the therapeutic drug can be increased, and on the other hand, the side effects caused by systemic administration can be avoided.
According to the results of current clinical trials, drug-eluting stents can reduce the incidence of restenosis after coronary intervention. If it is a simple balloon, the proportion of certain clinical symptoms caused by re-stenosis of the blood vessels can be as high as 50%. If implanted in a bare metal stent, the restenosis rate is reduced to 20-30%. With implanted drug-coated stents (such as palpitations), the restenosis rate can be reduced to less than 10%.
Various drug-coated stents contain different drugs or contents, different mechanisms of action, and different rates of drug release, so the utility and safety of the clinical application needs to be confirmed by rigorous and extensive clinical research.
—— Information from: Sohu Health

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