Release date: 2015-01-20 In order to improve the tissue repair ability and cardiac function of patients with myocardial infarction, proteins based on the use of bone marrow-derived cells through the paracrine pathway are increasingly becoming a core therapeutic approach. After collecting proteins secreted from bone marrow-derived cells from patients with acute myocardial infarction, the researchers used bioinformatics methods to analyze their segregation profiles. After functional screening, they discovered a secreted protein encoded by the C19orf10 gene (open reading frame on chromosome 19, located at the 19th chromatin open reading frame), which promotes cardiomyocyte survival and angiogenesis. The researchers also found that bone marrow-derived monocytes and macrophages can endogenously produce this protein and protect and repair the heart after myocardial infarction, and they named the protein as myeloid growth factor (MYDGF, myeloid). -derived growth factor). Mydgf knockout mice exhibited greater infarct scars and more severe systolic dysfunction compared to wild type mice. Restoration of Mydfg gene expression significantly attenuated the contractile function of infarct scars and myocardium after emergency infarction. This study is the first to report the biological function of myeloid growth factor and may serve as a typical example of a functional protein-based repair of ischemic tissue therapy. Source: Bio Valley Food Additives Powder,Sophora Extract,Propoli Liquid Extract,Apple Cider Vinegar Powder Fufeng Sinuote Biotechnology Co.,Ltd. , https://www.sinuotebio.com
Myocardial infarction--myeloid growth factor-mediated myocardial repair