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An international research team consisting of a number of institutions, including Nagoya University in Japan, recently announced that they have successfully discovered which protein the anti-diabetic drug "METFORMIN" specifically acts on. This is the first time in the world to find out the role of drugs at the cell level. The specific results have been published in well-known scientific journals in the United States. This achievement will be used to improve existing drugs.
Metformin acts primarily on the liver and muscles of the human body. Although it has been shown that the drug has the effect of lowering blood sugar levels, scientists have been unable to ascertain which proteins it acts on cells.
A team led by Professor You Young Jai of Nagoya University confirmed that metformin acts on a protein called "NHE". The NHE protein acts as a "porter" for ingesting and transporting substances in cells. The speed of the transported material can be finely adjusted by controlling the pH.
Professor You said that metformin will enhance the transport of substances in cells that are weakened by diabetes through NHE protein.
The researchers used the nematode to conduct related experiments. When investigating mutations in the nematode genetics, it was found that nematodes of NHE protein could not be produced, and metformin would have no effect on it. For fruit flies that use genetic recombination techniques to make NHE proteins, metformin is equally ineffective. Related studies have confirmed that metformin is responsible for the action of NHE protein to treat diabetes.
Japanese scientists discover specific anti-diabetic drugs
[China Pharmaceutical Network Technology News] It is reported that Japanese scientists have successfully discovered which protein the anti-diabetic drug "METFORMIN" specifically acts on. This is the first time in the world to detect drugs at the cell level. Experts say that metformin will enhance the transport of substances in cells that are weakened by diabetes through NHE protein.
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