The first epigenetic test to diagnose the origin of cancer

On August 26th, Manel Esteller, a professor of genetics at the University of Barcelona, ​​presented a new invention of epigenetic detection technology, EPICUP, in The Lancet Oncology, a technology that diagnoses the origin of tumors and enables doctors to Tumor types to develop more specific treatment options.

For cancer patients, primary diagnosis often involves detecting the primary tumor and whether metastasis will occur. However, 5%-10% of human tumors have the opposite diagnosis, that is, the metastatic tumor is often diagnosed first, and the primary tumor cannot be detected after using various diagnostic tests. This condition is also called unknown primary. Tumor tumor (CUP). Since the type of tumor is not known, the survival rate of these patients is very limited.

Professor Manel Esteller, an ICREA researcher and director of Epibiology and Cancer Bioengineering (PEBC) at the Bellvitge Institute of Biomedical Research (IDIBELL), said, “A few years ago, we began to recognize the chemical patterns that regulate gene activity (apparent) Genetics) varies from tissue to tissue, for example, in pancreatic and lung cells. We have analyzed the epigenetic characteristics of each cancer through more than 10,000 human tumor samples. When transferring the DNA of a tumor, we can judge which family it belongs to by the obtained epigenetic image, such as pancreatic cancer, colorectal cancer, lung cancer or breast cancer. In other words, we can use this method. Diagnose the origin of the tumor."

Determining the type of cancer by epigenetic testing will have a significant impact on treatment. “From now on, patients will not be treated blindly because we are able to provide more specific treatments for different types of tumors; in fact, our preliminary data show that this approach doubles patient survival.” Professor Esteller said, “It is important to remember that this is not an untapped area. Now we have worked with Ferrer Labs to make the promotion and application of this method possible.”

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